Octanoyl chloride → HCID 22341492, compound

HRID 584996Notes

Reaction equation

HRID 584996 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:10]=1[CH2:11][NH:12][CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](Cl)(=[O:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:10]=1[CH2:11][N:12]([CH3:13])[C:19](=[O:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8124Octanoyl chlorideHCID 4722225HCID 4722225, compound

Product 1

HCID 22341492HCID 22341492, compound

Procedure

In a manner similar to that of Example 37(e), by reacting 6 g (19.6 mmol) of N-(2-benzyloxy-5-bromo benzyl)-N-methylamine with 3.4 ml (19.6 mmol) of octanoyl chloride, and after purification by chromatography on a column of silica eluted with a heptane/ethyl acetate mixture (8/2), 8 g (95%) of the expected product are obtained in the form of a colorless oil.

Workup

  1. customafter purification by chromatography on a column of silica
  2. washeluted with a heptane/ethyl acetate mixture (8/2), 8 g (95%) of the expected product
  3. customare obtained in the form of a colorless oil

Sources & evidence

ORD record
ord-59bb3098d6ce4621b0a85b24edfe9adb
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Reaction notes

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