反应详情

2.68 g (11 mmol) of 3-[N-(3,5-dichlorophenyl)pyrrole-2-carboxaldehyde are added to a solution of 2.12 g (11 mmol) of 5-acetylaminoindolin-2-one in 220 ml of ethanol containing 0.5 ml of piperidine. The reaction medium is heated under reflux for 3 hours. After cooling, the precipitate formed is drained, washed with twice 5 ml of ice-cold ethanol and dried under reduced pressure. 1.81 g (40%) of 3-[N-(3,5-dichlorophenyl)pyrrol-2-yl]-5-acetylaminoindolin-2-one are thus obtained in the form of a yellow solid whose characteristic is the following: melting point=267° C.

1. temperatureThe reaction medium is heated
2. temperatureunder reflux for 3 hours
3. temperatureAfter cooling
4. customthe precipitate formed
5. washwashed with twice 5 ml of ice-cold ethanol
6. customdried under reduced pressure