HCID 22339380, compound → HCID 22339553, compound

HRID 585132Notes

Reaction equation

HRID 585132 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:21]2[C:26](=[O:27])[NH:25][C:24](=[O:28])[CH:23]=[N:22]2)[CH:5]=[C:6]([Cl:20])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([N+:17]([O-])=O)[CH:10]=1>C(O)C.C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([N:21]2[C:26](=[O:27])[NH:25][C:24](=[O:28])[CH:23]=[N:22]2)[CH:5]=[C:6]([Cl:20])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([NH2:17])[CH:10]=1

Participants

5

Reactant 1

HCID 22339380HCID 22339380, compound

Product 1

HCID 22339553HCID 22339553, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2-[3,5-dichloro-4-(4-methoxy-3-nitro-phenoxy)-phenyl]-2H-[1,2,4]triazine-3,5-dione (1.1 g) in ethanol (40 mL) and ethyl acetate (4 mL) was hydrogenated (45 psi which is about 3.1 atm) over 10% palladium-on-carbon (300 mg) for 4 h. The reaction was filtered and concentrated in vacuo to afford the title compound of Step A as a dark foam, 1.0 g.

Workup

  1. customfor 4 h
  2. filtrationThe reaction was filtered
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1be964185dba4b7494b5864b8e778453
Source dataset
uspto-grants-2005_08
Patent number
US06930107B2

Reaction notes

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