反应详情

温度

110 °C

To the N-[2-(1-pyrrolidinylmethyl)-6-quinolinyl]acetamide (5.53 g, 20.5 mmol) obtained in 1) of Example 7 was added concentrated hydrochloric acid (100 ml), the mixture was stirred at 110° C. for 1 hour, and the solvent was distilled off under reduced pressure. To the resulting residue was added ethyl acetate, the mixture was washed with an aqueous potassium carbonate solution and an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain the titled compound (4.56 g) as a powder from ethyl acetate-hexane.

1. distillationthe solvent was distilled off under reduced pressure
2. additionTo the resulting residue was added ethyl acetate
3. washthe mixture was washed with an aqueous potassium carbonate solution
4. dry with materialan aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate
5. distillationthe solvent was distilled off under reduced pressure