Hydrogen Bromide → HCID 22340340, compound

HRID 585309Notes

Reaction equation

HRID 585309 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH2:13][N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH:7]=[CH:6]2.[BrH:19]>O>[BrH:19].[N:14]1([CH2:13][C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[CH:4]=[C:3]([OH:2])[CH:12]=[CH:11]3)[CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 22340335HCID 22340335, compound

Product 1

HCID 22340340HCID 22340340, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A solution of the 1-[(6-methoxy-2-naphthyl)methyl]pyrrolidine (3.63 g, 15.0 mmol) obtained in Reference Example 21 in 48% hydrobromic acid (75 ml) was stirred at 100° C. for 6 hours. The reaction solution was diluted with water, the produced crystals were collected, and washed with water, tetrahydrofuran and diisopropyl ether to obtain the titled compound (2.45 g) as a colorless powder.

Workup

  1. customthe produced crystals were collected
  2. washwashed with water, tetrahydrofuran and diisopropyl ether

Sources & evidence

ORD record
ord-4881ca4b2e004818bb527fba48b8d94a
Source dataset
uspto-grants-2005_08
Patent number
US06930185B2

Reaction notes

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