反应详情

4-Methylbenzothioamide (0.312 g; 2.00 mmol) and ethyl 2-chloro-3-oxobutanoate (0.323 mL; 2.10 mmol) were dissolved in ethanol (3 mL). The mixture was irradiated in a microwave oven at 170° C. for 10 min. After evaporation, the residue was purified by flash chromatography on silica gel (eluent: 20 to 100% dichloromethane in heptane) to afford 0.359 g (69%) of ethyl 4-methyl-2-p-tolylthiazole-5-carboxylate as a solid.

1. customThe mixture was irradiated in a microwave oven at 170° C. for 10 min
2. customAfter evaporation
3. customthe residue was purified by flash chromatography on silica gel (eluent: 20 to 100% dichloromethane in heptane)