HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenethylamine, (-)- → (4aS,8aR)-4-(3,4-Diethoxy-phenyl)-2-piperidin-4-yl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenethylamine, (-)- | HCID 75818 | — |
| Reactant | (cis)-2-(3,4-Diethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid | HCID 10925192 | — |
| Reactant | 2,6-Dichloro-3-fluoroacetophenone | HCID 22311317 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (4aS,8aR)-4-(3,4-Diethoxy-phenyl)-2-piperidin-4-yl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride | HCID 68877453 | — |
Reaction Steps
Prepared from the salt of (S)-(−)-α-methylbenzylamine, (cis)-2-(3,4-diethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid (compound P) and piperidin-4-yl-hydrazine dihydrochloride in 2-propanol as described for compound 5d. M. p. 248-250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06933296B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-9955cfde85604f27bcee8f419b85b889 |
| Source note | uspto-grants-2005_08 |