(R)-2-(3-tert-butyl-ureido)-propionic acid → 1-tert-Butyl-3-((S)-2-{4-[(4aS,8aR)-4-(3,4-dimethoxy-phenyl)-1-oxo-4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-piperidin-1-yl}-1-methyl-2-oxo-ethyl)-urea

Participants

Role	Name	HCID	Charge
Reactant	(R)-2-(3-tert-butyl-ureido)-propionic acid	HCID 28785982	—
Reactant	(4aS,8aR)-4-(3,4-Dimethoxy-phenyl)-2-piperidin-4-yl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one	HCID 68878852	—
Reactant	(4-{4-[(4aS,8aR)-4-(3,4-Dimethoxy-phenyl)-1-oxo-4a,5,8,8a-tetrahydro 1H-Phthalazin-2-yl]-piperidin-1-yl}-4-oxo-butyl)-carbamic Acid Tert Butyl Ester	HCID 86759810	—
Product	1-tert-Butyl-3-((S)-2-{4-[(4aS,8aR)-4-(3,4-dimethoxy-phenyl)-1-oxo-4a,5,8,8a-tetrahydro-1H-phthalazin-2-yl]-piperidin-1-yl}-1-methyl-2-oxo-ethyl)-urea	HCID 69798693	—

Prepared from compound 5c and (R)-2-(3-tert-butyl-ureido)-propionic acid (N-boc-L-alanine) as described for compound 5b. M. p. 153-154° C.