2,4-Difluorobenzaldehyde → Methyl(S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(2,4-difluorobenzylamino)propionate

HRID 585528Notes

Reaction equation

HRID 585528 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10](C)=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C@H:24]([NH:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)[C:25]([O:27][CH2:28]C)=[O:26])=[CH:19][CH:18]=1.[F:39]C1C=C(F)C=CC=1C=O>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:14][CH2:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:23][C@H:24]([NH:30][CH2:31][C:32]2[CH:33]=[CH:34][C:35]([F:38])=[CH:36][C:37]=2[F:39])[C:25]([O:27][CH3:28])=[O:26])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 737702,4-DifluorobenzaldehydeHCID 12149026Ethyl(S)-3-[4-[2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy]phenyl]-2-(4-fluorobenzylamino)propionate

Product 1

HCID 69731855Methyl(S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(2,4-difluorobenzylamino)propionate

Procedure

In the same manner as in Example 7, 243.9 mg of the title compound was obtained as colorless amorphous compound from 421.3 mg of Referential Compound 3 and 240 μL of 2,4-difluorobenzaldehyde.

Sources & evidence

ORD record
ord-74563bd5f9034483904219a118c4952d
Source dataset
uspto-grants-2005_08
Patent number
US06933309B2

Reaction notes

Loading…