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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 585528Generated: October 27, 2026

2,4-Difluorobenzaldehyde → Methyl(S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(2,4-difluorobenzylamino)propionate

https://huagongshe.com/reaction/585528

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DifluorobenzaldehydeHCID 73770—
ReactantEthyl(S)-3-[4-[2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy]phenyl]-2-(4-fluorobenzylamino)propionateHCID 12149026—
ProductMethyl(S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(2,4-difluorobenzylamino)propionateHCID 69731855—

Reaction Steps

In the same manner as in Example 7, 243.9 mg of the title compound was obtained as colorless amorphous compound from 421.3 mg of Referential Compound 3 and 240 μL of 2,4-difluorobenzaldehyde.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06933309B2
Source datasetuspto-grants-2005_08
ORD IDord-74563bd5f9034483904219a118c4952d
Source noteuspto-grants-2005_08