2,3-Difluorobenzaldehyde → Methyl(S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(2,3-difluorobenzylamino)propionate

HRID 585530Notes

Reaction equation

HRID 585530 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10](C)=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C@H:24]([NH:30][CH2:31]C2C=CC(F)=CC=2)[C:25]([O:27][CH2:28]C)=[O:26])=[CH:19][CH:18]=1.[F:39][C:40]1[C:47]([F:48])=[CH:46][CH:45]=[CH:44][C:41]=1C=O>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C@H:24]([NH:30][CH2:31][C:46]2[CH:45]=[CH:44][CH:41]=[C:40]([F:39])[C:47]=2[F:48])[C:25]([O:27][CH3:28])=[O:26])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 1376642,3-DifluorobenzaldehydeHCID 12149026Ethyl(S)-3-[4-[2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy]phenyl]-2-(4-fluorobenzylamino)propionate

Product 1

HCID 69732747Methyl(S)-3-[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-(2,3-difluorobenzylamino)propionate

Procedure

In the same manner as in Example 7, 253.2 mg of the title compound was obtained as colorless oil from 510.0 mg of Referential Compound 3 and 191 μL of 2,3-difluorobenzaldehyde.

Sources & evidence

ORD record
ord-f81bb5740b584c95b518089db0d3a81e
Source dataset
uspto-grants-2005_08
Patent number
US06933309B2

Reaction notes

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