Sodium Methoxide → HCID 86759813, compound

HRID 585535Notes

Reaction equation

HRID 585535 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C@H:23]([NH:27][CH2:28][C:29]2[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=2)[C:24]([OH:26])=[O:25])=[CH:18][CH:17]=1.C[O-].[Na+:38]>CO>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C@H:23]([NH:27][CH2:28][C:29]2[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=2)[C:24]([O-:26])=[O:25])=[CH:18][CH:17]=1.[Na+:38]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 12149031HCID 12149031, compound

Product 1

HCID 86759813HCID 86759813, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 18 (1.57 g) was suspended in methanol (30 mL), and sodium methoxide was added to the resultant mixture until an substantially homogeneous solution was obtained. The solution was filtered, and the filtrate was concentrated. Diethyl ether was added thereto, and the resultant colorless crystals were collected through filtration and dried under reduced pressure, to thereby yield 1.57 g of the title compound.

Workup

  1. customwas obtained
  2. filtrationThe solution was filtered
  3. concentrationthe filtrate was concentrated
  4. additionDiethyl ether was added
  5. filtrationthe resultant colorless crystals were collected through filtration
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-6a72eb87892042ac8342630520857dfa
Source dataset
uspto-grants-2005_08
Patent number
US06933309B2

Reaction notes

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