反应详情

The product from step 3 (50.4 mg, 0.10 mmoles) was stirred at RT in 1:1 mix of TFA and dichloromethane (2 mL) for 30 min. The solvent was removed under reduced pressure to give the product 56.2 mg (99%). 1H NMR (CD3OD) δ 7.84-7.79 (m, 2H), 7.39-7.35 (m, 2H), 7.32-7.26 (m, 2H), 7.22-7.17 (t, 1H), 6.95 (d, 1H), 6.82 (t, 1H), 3.37 (t, 2H), 3.22-3.02 (series of m, 4H), 2.81 (t, 2H), 2.65-2.57 (series of m, 2H), 2.49 (t, 1H), 1.92-1.82 (series of m, 2H), 1.80-1.72 (series of m, 2H); MS (ESI+) for C22H26N4O3S m/z 427 (M+H)+.

1. customThe solvent was removed under reduced pressure