反应详情

(±)-3-[2,4-Bis(methoxymethoxy)phenyl]cyclohexanone (80 mg) and piperazine (24 mg) were dissolved in dichloroethane (5 ml) and stirred at ambient temperature for 1 hr under argon. Tetramethylammonium triacetoxyborohydride (79 mg) was added and stirring continued under argon. After 16 hr, additional portions of piperazine (24 mg) and tetramethylammonium triacetoxyborohydride (79 mg) were added and stirring continued. After a further 6 hr, glacial acetic acid was added dropwise until a solution was obtained, and stirring continued at ambient temperature. After a further 16 hr, the reaction mixture was partitioned between sodium hydrogen carbonate (20 ml of a saturated solution) and ethyl acetate. The aqueous layer was extracted with ethyl acetate (3×20 ml), and the combined organic extracts were dried over magnesium sulfate and evaporated in vacuo. The crude residue was purified by flash column chromatography chromatography (SiO2, dichloromethane/methanol, 9:1 v/v) to furnish the title compound as an off white solid (52 mg, 53%) and mixture of diastereoisomers; m/z (ES+) 365 (M+H)+.

1. stirringstirring
2. waitAfter 16 hr
3. stirringstirring
4. waitAfter a further 6 hr
5. customwas obtained
6. stirringstirring
7. customcontinued at ambient temperature
8. waitAfter a further 16 hr
9. customthe reaction mixture was partitioned between sodium hydrogen carbonate (20 ml of a saturated solution) and ethyl acetate
10. extractionThe aqueous layer was extracted with ethyl acetate (3×20 ml)
11. dry with materialthe combined organic extracts were dried over magnesium sulfate
12. customevaporated in vacuo
13. customThe crude residue was purified by flash column chromatography chromatography (SiO2, dichloromethane/methanol, 9:1 v/v)