Sodium borohydride → HCID 20824481, compound

HRID 585730Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[CH:16]=[CH:15][C:8]2[C:9](=[O:14])[CH2:10][CH2:11][CH2:12][S:13][C:7]=2[CH:6]=1)=[O:4].[BH4-].[Na+]>>[CH3:1][O:2][C:3]([C:5]1[CH:16]=[CH:15][C:8]2[CH:9]([OH:14])[CH2:10][CH2:11][CH2:12][S:13][C:7]=2[CH:6]=1)=[O:4]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 20824482HCID 20824482, compound

Product 1

HCID 20824481HCID 20824481, compoundYield 98%

Procedure

By a similar reaction operation as in Starting Material Synthetic Example 1 using 5-oxo-2,3,4,5-tetrahydro-1-benzothiepine-8-carboxylic acid methyl ester (3.30 g) and sodium borohydride (529 mg), the objective 5-hydroxy-2,3,4,5-tetrahydro-1-benzothiepine-8-carboxylic acid methyl ester (3.26 g) was obtained a pale yellow oil.

Sources & evidence

ORD record: ord-206d5e5e053b4761bc2f729d9d760813
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06933305B2

Reaction notes

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