Benzyl chloroformate → HCID 69619662, compound

HRID 585733Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([NH2:15])[CH2:10][CH2:11][O:12]2)=[CH:7][CH:6]=1)=[O:4].[CH2:16]([O:23][C:24](Cl)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([NH:15][C:24]([O:23][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:25])[CH2:10][CH2:11][O:12]2)=[CH:7][CH:6]=1)=[O:4]

Participants

Reactant 2

HCID 10387Benzyl chloroformate

HCID 20824488HCID 20824488, compound

Product 1

HCID 69619662HCID 69619662, compound

Procedure

By a similar reaction operation as in Starting Material Synthetic Example 4 using 4-aminochromane-7-carboxylic acid methyl ester (1.4 g) and benzyloxycarbonyl chloride (2.0 ml), the objective 4-(benzyloxycarbonylamino)chromane-7-carboxylic acid methyl ester (1.9 g) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-b6f67aca30024b4e86bc0516775654a6
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06933305B2

Reaction notes

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