Benzyl chloroformate → HCID 69619691, compound

HRID 585736Notes

Reaction equation

HRID 585736 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([C@H:9]([NH2:15])[CH2:10][CH2:11][S:12]2)=[CH:7][CH:6]=1)=[O:4].[CH2:16]([O:23][C:24](Cl)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([C@H:9]([NH:15][C:24]([O:23][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:25])[CH2:10][CH2:11][S:12]2)=[CH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 10387Benzyl chloroformateHCID 59089473Methyl (4R)-4-amino-3,4-dihydro-2H-1-benzothiopyran-7-carboxylate

Product 1

HCID 69619691HCID 69619691, compound

Procedure

By a similar reaction operation as in Starting Material Synthetic Example 4 using (R)-4-aminothiochromane-7-carboxylic acid methyl ester (5.70 g) and benzyloxycarbonyl chloride (5.50 ml), the objective (R)-4-(benzyloxycarbonylamino)thiochromane-7-carboxylic acid methyl ester (7.35 g) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-4eed9b002f654dc5abab9c5a98ce476b
Source dataset
uspto-grants-2005_08
Patent number
US06933305B2

Reaction notes

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