Potassium Carbonate → HCID 59089460, compound

HRID 585747Notes

Reaction equation

C[O:2][C:3]([C:5]1[C:14]([CH3:15])=[C:13]2[C:8]([C@@H:9]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:10][CH2:11][S:12]2)=[CH:7][CH:6]=1)=[O:4].C(=O)([O-])[O-].[K+].[K+]>>[C:20]([O:19][C:17]([NH:16][C@@H:9]1[C:8]2[C:13](=[C:14]([CH3:15])[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=2)[S:12][CH2:11][CH2:10]1)=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

Reactant 2

HCID 11430Potassium Carbonate

HCID 59089480HCID 59089480, compound

Product 1

HCID 59089460HCID 59089460, compoundYield 84.7%

Procedure

By a similar reaction operation as in Starting Material Synthetic Example 6 using (S)-4-(tert-butoxycarbonylamino)-8-methylthiochromane-7-carboxylic acid methyl ester (5.00 g) and potassium carbonate (6.13 g), the objective (S)-4-(tert-butoxycarbonylamino)-8-methylthiochromane-7-carboxylic acid (4.06 g) was obtained as a colorless amorphous solid.

Sources & evidence

ORD record: ord-74852714f47d4013a5d70ac320fa7cd9
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06933305B2

Reaction notes

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