HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → (S)-4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | 2-Chloro-1-methylpyridinium iodide | HCID 167069 | — |
| Reactant | (S)-4-(tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid | HCID 59089485 | — |
| Product | (S)-4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide | HCID 59089457 | 87.4% |
Reaction Steps
By a similar reaction operation as in Starting Material Synthetic Example 53 using (S)-4-(tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid (1.00 g), 4-aminopyridine (321 mg) and 2-chloro-1-methylpyridinium iodide (949 mg), the objective (S)-4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide (1.08 g) was obtained as a pale-brown amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06933305B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-a63e5f2ae2654d0f88f5561371f85e9d |
| Source note | uspto-grants-2005_08 |