HRID585752

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1727

4-Aminopyridine

C5H6N2

HCID167069

2-Chloro-1-methylpyridinium iodide

C6H7ClIN

结构：Cc1cc2c(cc1C(=O)O)SCC[C@@H]2NC(=O)OC(C)(C)C

HCID59089485

未命名化合物

PRODUCTS

生成物

结构：Cc1cc2c(cc1C(=O)Nc1ccncc1)SCC[C@@H]2NC(=O)OC(C)(C)C

HCID59089457

未命名化合物

收率 87.4%

PROCEDURE

实验过程

By a similar reaction operation as in Starting Material Synthetic Example 53 using (S)-4-(tert-butoxycarbonylamino)-6-methylthiochromane-7-carboxylic acid (1.00 g), 4-aminopyridine (321 mg) and 2-chloro-1-methylpyridinium iodide (949 mg), the objective (S)-4-(tert-butoxycarbonylamino)-6-methyl-N-(4-pyridyl)thiochromane-7-carboxamide (1.08 g) was obtained as a pale-brown amorphous solid.