HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → (S)-4-(tert-butoxycarbonylamino)-6-chloro-N-(4-pyridyl)thiochromane-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | 2-Chloro-1-methylpyridinium iodide | HCID 167069 | — |
| Reactant | (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid | HCID 59089433 | — |
| Product | (S)-4-(tert-butoxycarbonylamino)-6-chloro-N-(4-pyridyl)thiochromane-7-carboxamide | HCID 59089456 | 103.9% |
Reaction Steps
By a similar reaction operation as in Starting Material Synthetic Example 53 using (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid (250 mg), 4-aminopyridine (68.4 mg) and 2-chloro-1-methylpyridinium iodide (222 mg), the objective (S)-4-(tert-butoxycarbonylamino)-6-chloro-N-(4-pyridyl)thiochromane-7-carboxamide (317 mg) was obtained as a colorless amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06933305B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-8b9483bb90b44b0780cb30c92ea84652 |
| Source note | uspto-grants-2005_08 |