Potassium Carbonate → HCID 69619653, compound

HRID 585762Notes

Reaction equation

C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([C@@H:9]([NH:15][C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:10][CH2:11][S:12]2)=[CH:7][C:6]=1[Cl:26])=[O:4].C(=O)([O-])[O-].[K+].[K+]>>[CH2:19]([O:18][C:16]([NH:15][C@@H:9]1[C:8]2[C:13](=[CH:14][C:5]([C:3]([OH:4])=[O:2])=[C:6]([Cl:26])[CH:7]=2)[S:12][CH2:11][CH2:10]1)=[O:17])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 11430Potassium Carbonate

HCID 69619715HCID 69619715, compound

Product 1

HCID 69619653HCID 69619653, compoundYield 98%

Procedure

By a similar reaction operation as in Starting Material Synthetic Example 6 using (S)-4-(benzyloxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid methyl ester (450 mg) and potassium carbonate (317 mg), the objective (S)-4-(benzyloxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid (425 mg) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-1508346120a24cbb8e352d5c50964c3a
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06933305B2

Reaction notes

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