Potassium Carbonate → HCID 22337423, compound

HRID 585763Notes

Reaction equation

C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:10][CH2:11][S:12]2)=[CH:7][C:6]=1[O:23][CH3:24])=[O:4].C(=O)([O-])[O-].[K+].[K+]>>[C:19]([O:18][C:16]([NH:15][CH:9]1[C:8]2[C:13](=[CH:14][C:5]([C:3]([OH:4])=[O:2])=[C:6]([O:23][CH3:24])[CH:7]=2)[S:12][CH2:11][CH2:10]1)=[O:17])([CH3:22])([CH3:20])[CH3:21]

Participants

Reactant 2

HCID 11430Potassium Carbonate

HCID 20824506HCID 20824506, compound

Product 1

HCID 22337423HCID 22337423, compoundYield 94%

Procedure

By a similar reaction operation as in Starting Material Synthetic Example 6 using 4-(tert-butoxycarbonylamino)-6-methoxythiochromane-7-carboxylic acid methyl ester (800 mg) and potassium carbonate (627 mg), the objective 4-(tert-butoxycarbonylamino)-6-methoxythiochromane-7-carboxylic acid (722 mg) was obtained as colorless crystals.

Sources & evidence

ORD record: ord-c0e07aa45aad4f9c97c8a26eaa2f3163
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06933305B2

Reaction notes

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