6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → HCID 66832065, compound

HRID 58582Notes

Reaction equation

HRID 58582 reaction equation
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[N:13]1([C:18]2[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=2)[NH2:21])[CH:17]=[CH:16][CH:15]=[CH:14]1>C(O)C>[N:13]1([C:18]2[CH:19]=[C:20]([N:21]3[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]3=[O:11])[CH:22]=[CH:23][CH:24]=2)[CH:14]=[CH:15][CH:16]=[CH:17]1

Participants

4

Reactant 2

HCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dioneHCID 27605463-(1H-pyrrol-1-yl)aniline

Product 1

HCID 66832065HCID 66832065, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g, 1.47 mmol) and 3-(1H-pyrrol-1-yl)aniline (0.697 g; 4.41 mmol) in ethanol (3 mL). 1-(3-(1H-pyrrol-1-yl)phenyl)-2-oxopyrrolidine-3-carboxylic acid 0.313 g (80%) was obtained as a brown oil.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-6ec33ae0a78f412e9339409783ff247a
Source dataset
uspto-grants-2016_09
Patent number
US09434722B2

Reaction notes

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