Hydrochloric Acid → HCID 22338301, compound

HRID 585898Notes

Reaction equation

HRID 585898 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]2[CH2:7][CH2:8][C:9]3[CH:10]=[N:11][N:12]([C:14]([NH2:17])([CH3:16])[CH3:15])[C:13]=3[C:5]=2[CH:4]=1.[ClH:20]>>[ClH:20].[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]2[CH2:7][CH2:8][C:9]3[CH:10]=[N:11][N:12]([C:14]([NH2:17])([CH3:16])[CH3:15])[C:13]=3[C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22338302HCID 22338302, compound

Product 1

HCID 22338301HCID 22338301, compoundYield 53%

Procedure

The product from Step A (0.030 g, 0.12 mmol) was dissolved in 0.1 N HCl and the solution was concentrated to give a white solid (0.021 g, 53%): 1H NMR (CDCl3) δ 7.50 (s, 1H), 7.35 (d, J=8.4 Hz, 1H), 7.07 (d, J=2.4 Hz, 1H), 6.94 (dd, J=8.4, 2.4 Hz, 1H), 4.7 (m, 2H), 3.86 (m, 1H), 3.83 (s, 3H), 2.78 (t, J=7.2 Hz, 2H), 2.57 (m, 2H) 1.24 (d, J=6.6 Hz, 3H); MS m/z 258 [M+H]+, 241, 201. Analysis. Calculated for C15H19N3O.2HCl.0.25H2O: C, 53.82; H, 6.47; N, 12.55. Found: C, 53.86; H, 6.73; N, 12.51.

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-a3e23c564b634af08e4e4f0f1fe3e141
Source dataset
uspto-grants-2005_08
Patent number
US06933392B2

Reaction notes

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