Hydrochloric Acid → 5'-Adenylic acid, 2-(6-cyano-1-hexynyl)-

HRID 586123Notes

Reaction equation

HRID 586123 reaction equation
[P:1]([O:5][CH2:6][C@H:7]1[O:11][C@@H:10]([N:12]2[C:21]3[N:20]=[C:19]([C:22]#[C:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]#[N:29])[N:18]=[C:16]([NH2:17])[C:15]=3[N:14]=[CH:13]2)[C@H:9]([OH:30])[C@@H:8]1[OH:31])([O-:4])([O-:3])=[O:2].C([NH+](CC)CC)C.C([NH+](CC)CC)C.Cl>O>[P:1]([O:5][CH2:6][C@H:7]1[O:11][C@@H:10]([N:12]2[C:21]3[N:20]=[C:19]([C:22]#[C:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]#[N:29])[N:18]=[C:16]([NH2:17])[C:15]=3[N:14]=[CH:13]2)[C@H:9]([OH:30])[C@@H:8]1[OH:31])([OH:3])([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69595338Triethylammonium 2-(6-cyano-1-hexyn-1-yl)adenosine 5'-monophosphate

Product 1

HCID 98705725'-Adenylic acid, 2-(6-cyano-1-hexynyl)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A triethylammonium 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate (1.1 g) was dissolved in water (20 mL), and, under ice-cooling conditions, 1N HCl solution (2 mL) was added thereto, followed by standing for 10 minutes. After having been diluted with water (20 mL), the resultant mixture was filtered. The residue was washed with water (20 mL) and then with ethanol (20 mL×2), to thereby yield 617 mg of the above-titled compound as a colorless amorphous substance.

Workup

  1. additionwas added
  2. filtrationthe resultant mixture was filtered
  3. washThe residue was washed with water (20 mL)

Sources & evidence

ORD record
ord-1d0d0bb4528d40268441c64bcd55f4aa
Source dataset
uspto-grants-2005_08
Patent number
US06936596B2

Reaction notes

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