HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → n-Methoxy-n-methyl-2-(piperid-1-yl)-ethanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Bromo-N-methoxy-N-methylacetamide | HCID 10866961 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | n-Methoxy-n-methyl-2-(piperid-1-yl)-ethanamide | HCID 22329403 | — |
Reaction Steps
The above amide (1 equiv) is dissolved in THF. Piperidine (1.1 equiv) is added and the reaction solution is stirred at ambient temperature for 48 h. The reaction mixture is concentrated and the product is purified by flash chromatography on silica using MeOH/CH2Cl2 as the mobile phase to yield N-methoxy-N-methyl-2-(piperid-1-yl)-ethanamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06936606B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-8d7c8538ba714baa96f393401ab4ab4e |
| Source note | uspto-grants-2005_08 |