Piperidine → n-Methoxy-n-methyl-2-(piperid-1-yl)-ethanamide

HRID 586146Notes

Reaction equation

HRID 586146 reaction equation
[CH3:1][O:2][N:3]([CH3:8])[C:4](=[O:7])[CH2:5]Br.[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>C1COCC1>[CH3:1][O:2][N:3]([CH3:8])[C:4](=[O:7])[CH2:5][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 108669612-Bromo-N-methoxy-N-methylacetamide

Product 1

HCID 22329403n-Methoxy-n-methyl-2-(piperid-1-yl)-ethanamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The above amide (1 equiv) is dissolved in THF. Piperidine (1.1 equiv) is added and the reaction solution is stirred at ambient temperature for 48 h. The reaction mixture is concentrated and the product is purified by flash chromatography on silica using MeOH/CH2Cl2 as the mobile phase to yield N-methoxy-N-methyl-2-(piperid-1-yl)-ethanamide.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customthe product is purified by flash chromatography on silica

Sources & evidence

ORD record
ord-8d7c8538ba714baa96f393401ab4ab4e
Source dataset
uspto-grants-2005_08
Patent number
US06936606B2

Reaction notes

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