Ammonia → HCID 22329612, compound

HRID 586150Notes

Reaction equation

HRID 586150 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[Br-].[NH4+:11].N>>[BrH:1].[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:11])[NH2:7])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 12162Benzonitrile, 4-bromo-HCID 25514Ammonium Bromide

Product 1

HCID 22329612HCID 22329612, compound

Procedure

In an autoclave, 4-bromobenzonitrile (36.4 g, 200 mmol), ammonium bromide (39.2 g, 400 mmol) and ammonia gas (34.0 g, 2 mol) are heated to 140-150° C. under autogenous pressure for 9 h. The contents of the autoclave are concentrated and extracted by stirring with ethanol. The residue is filtered off and extracted again by stirring with ethanol. The extracts are combined and concentrated to about 100 ml. The precipitated solid is filtered off with suction, washed with ethanol and dried.

Workup

  1. concentrationThe contents of the autoclave are concentrated
  2. extractionextracted
  3. filtrationThe residue is filtered off
  4. extractionextracted again
  5. stirringby stirring with ethanol
  6. concentrationconcentrated to about 100 ml
  7. filtrationThe precipitated solid is filtered off with suction
  8. washwashed with ethanol
  9. customdried

Sources & evidence

ORD record
ord-5eb1dbb869b9486abd2b29e462aa4cec
Source dataset
uspto-grants-2005_08
Patent number
US06936609B2

Reaction notes

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