反应详情

温度

70 °C

A mixture of 3-(2-bromoethyl)-2-(triethylsilyl)-5-(trifluoromethyl)-1H-indole (0.448 g; 1.10 mmol) and sodium azide (0.215 g; 3.31 mmol) in DMF (10 mL) was stirred at 70° C. for 4 hours and concentrated under reduced pressure. The residue was diluted in ethyl acetate, washed with brine, dried and concentrated under reduced pressure to give 0.402 g (99%) of the title compound as a brown oil.

1. concentrationconcentrated under reduced pressure
2. additionThe residue was diluted in ethyl acetate
3. washwashed with brine
4. customdried
5. concentrationconcentrated under reduced pressure