Hydrochloric Acid → HCID 178419379, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(3-bromophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-[1,2,3]triazole (1.27 g, 3.6 mmol), 2 N HCl (30 ml) and ethanol (30 ml) was heated at 60° C. for 3 h. The reaction mixture was cooled to room temperature and concentrated to approximately 5 ml under reduced pressure. The resulting solid was filtered off and dried under vacuum to yield the title compound (776 mg, 97%): 1H NMR (360 MHz, DMSO-d6) δ 8.46 (1H, s), 8.07 (1H, s), 7.89 (1H, d, J 7.8 Hz), 7.55 (1H, d, J 7.8 Hz), 7.42 (1H, t, J 7.8 Hz).

Provenance & Evidence