Hydrochloric Acid → HCID 178419379, compound

HRID 586310Notes

Reaction equation

HRID 586310 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12](COCC[Si](C)(C)C)[N:11]=[N:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[N:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22329510HCID 22329510, compound

Product 1

HCID 178419379HCID 178419379, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 5-(3-bromophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-[1,2,3]triazole (1.27 g, 3.6 mmol), 2 N HCl (30 ml) and ethanol (30 ml) was heated at 60° C. for 3 h. The reaction mixture was cooled to room temperature and concentrated to approximately 5 ml under reduced pressure. The resulting solid was filtered off and dried under vacuum to yield the title compound (776 mg, 97%): 1H NMR (360 MHz, DMSO-d6) δ 8.46 (1H, s), 8.07 (1H, s), 7.89 (1H, d, J 7.8 Hz), 7.55 (1H, d, J 7.8 Hz), 7.42 (1H, t, J 7.8 Hz).

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. concentrationconcentrated to approximately 5 ml under reduced pressure
  3. filtrationThe resulting solid was filtered off
  4. customdried under vacuum

Sources & evidence

ORD record
ord-d445227782f64bcab978716a8ab588fc
Source dataset
uspto-grants-2005_08
Patent number
US06936608B2

Reaction notes

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