Bis(neopentyl glycolato)diboron → 4-Fluoro-3-([1,2,4]triazol-1-yl)phenylboronic acid

HRID 586336Notes

Reaction equation

HRID 586336 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:13])=[C:6]([N:8]2[CH:12]=[N:11][CH:10]=[N:9]2)[CH:7]=1.[B:14]1(B2OCC(C)(C)CO2)[O:19]CC(C)(C)C[O:15]1>>[F:13][C:5]1[CH:4]=[CH:3][C:2]([B:14]([OH:19])[OH:15])=[CH:7][C:6]=1[N:8]1[CH:12]=[N:11][CH:10]=[N:9]1

Participants

3

Reactant 2

HCID 2734316Bis(neopentyl glycolato)diboronHCID 223295421-(5-Bromo-2-fluorophenyl)-1h-[1,2,4]triazole

Product 1

HCID 223294894-Fluoro-3-([1,2,4]triazol-1-yl)phenylboronic acid

Procedure

1-(5-Bromo-2-fluorophenyl)-1H-[1,2,4]triazole (1.1 g, 4.5 mmol) was reacted with bis(neopentyl glycolato)diboron (1.13 g, 5.0 mmol) using the method in Example 49 to give 4-fluoro-3-([1,2,4]triazol-1-yl)phenylboronic acid as a white solid: MS (ES+) m/z 208 [M+H]+.

Sources & evidence

ORD record
ord-0b1efe95fb4345a696d7b41555c1fe54
Source dataset
uspto-grants-2005_08
Patent number
US06936608B2

Reaction notes

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