7-Bromo-3-trifluoromethyl-imidazo[1,2-B][1,2,4]triazine → HCID 10269265, compound

HRID 586337Notes

Reaction equation

HRID 586337 reaction equation
Br[C:2]1[N:6]2[N:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[N:10][C:5]2=[N:4][CH:3]=1.[F:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][C:17]=1[N:25]1[CH:29]=[N:28][CH:27]=[N:26]1>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[N:6]3[N:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[N:10][C:5]3=[N:4][CH:3]=2)=[CH:18][C:17]=1[N:25]1[CH:29]=[N:28][CH:27]=[N:26]1

Participants

3

Reactant 2

HCID 116014167-Bromo-3-trifluoromethyl-imidazo[1,2-B][1,2,4]triazineHCID 223294894-Fluoro-3-([1,2,4]triazol-1-yl)phenylboronic acid

Product 1

HCID 10269265HCID 10269265, compound

Procedure

7-Bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine was coupled with 4-fluoro-3-([1,2,4]triazol-1-yl)phenylboronic acid as described in Example 3, step f, final paragraph, to give the title compound: 1H NMR (360 MHz, DMSO-d6) δ 7.82 (1H, dd, J 8.7, 10.5 Hz), 8.34-8.39 (1H, m), 8.39 (1H, s), 8.71 (1H, dd, J 2.4, 7.4 Hz), 9.02 (1H, s), 9.13 (1H, d, J 2.4 Hz); MS (ES+) m/z 350 [M+H]+.

Sources & evidence

ORD record
ord-311be3471d0f491cbfa35335f64b9911
Source dataset
uspto-grants-2005_08
Patent number
US06936608B2

Reaction notes

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