反应详情

A mixture of 2-aminothiazole (2 g, 20 mmol) and 3-bromo-2-oxo-pentanoic acid ethyl ester (4.4 g, 20 mmol) in ethanol (40 mL) is refluxed for 20 h. The solvent is removed in vacuo until dryness. The residue is purified by column chromatography (5% methanol in methylene chloride) to give 5-ethyl-imidazo[2,1-b]thiazole-6-carboxylic acid ethyl ester as an oil. Step 2. Preparation of 5-ethyl-6-hydroxymethyl-imidazo[2,1-b]thiazole

1. temperatureis refluxed for 20 h
2. customThe solvent is removed in vacuo until dryness
3. customThe residue is purified by column chromatography (5% methanol in methylene chloride)