HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 586399Generated: October 25, 2026
1-Fluoro-3-nitrobenzene → 1-Methyl-4-(3-nitrophenyl)piperazine
https://huagongshe.com/reaction/586399
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Fluoro-3-nitrobenzene | HCID 9823 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Product | 1-Methyl-4-(3-nitrophenyl)piperazine | HCID 12152161 | — |
Reaction Steps
A mixture of 3-fluoronitrobenzene (20 ml; 0.19 mol) and 1-methylpiperazine (40 ml; 0.36 mol) was heated to 120° C. for a week. The cooled mixture was purified by column-chromatography on silica gel using a mixture of ethyl acetate and methanol (9:1 v/1) as the eluent. Yield: 33 g (79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06936613B2 |
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| Source dataset | uspto-grants-2005_08 |
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| ORD ID | ord-ee474b006a704546bf9351a9bd8a51d2 |
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| Source note | uspto-grants-2005_08 |
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