反应详情

温度

120 °C

A mixture of 3-fluoronitrobenzene (20 ml; 0.19 mol) and 1-methylpiperazine (40 ml; 0.36 mol) was heated to 120° C. for a week. The cooled mixture was purified by column-chromatography on silica gel using a mixture of ethyl acetate and methanol (9:1 v/1) as the eluent. Yield: 33 g (79%).

1. customThe cooled mixture was purified by column-chromatography on silica gel using
2. additiona mixture of ethyl acetate and methanol (9:1 v/1) as the eluent