反应详情

温度

60 °C

Sodium azide (1.80 g; 27.65 mmol) was added to a solution of 4-(triethylsilyl)but-3-ynyl 4-methylbenzenesulfonate (3.12 g; 9.22 mmol) in DMF (15 mL) and stirred at 60° C. for 3 hours. After cooling, the volatiles were removed under reduced pressure and the residue was partitioned between saturated ammonium chloride and ethyl acetate. The organic layer was dried and concentrated under reduced pressure to afford 2.0 g (quantitative yield) of (4-azidobut-1-ynyl)triethylsilane as a colorless oil.

1. temperatureAfter cooling
2. customthe volatiles were removed under reduced pressure
3. customthe residue was partitioned between saturated ammonium chloride and ethyl acetate
4. customThe organic layer was dried
5. concentrationconcentrated under reduced pressure