Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22329431 | HCID 22329431 | 48.3% |
Reaction Steps
A mixture of 2-fluoro-4-methyl-1-nitrobenzene (250 mg, 1.6 mmol), triethylamine (200 mg, 2.0 mmol), and 2-propanamine (200 mg, 3.4 mmol) in tetrahydrofuran (1 mL) was heated at 25° C. for 5 hours. The crude product was purified by preparative thin-layer chromatography [eluent: hexane/EtOAc (1:2)], giving the desired product (150 mg, 48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06936607B2 |
|---|
| Source dataset | uspto-grants-2005_08 |
|---|
| ORD ID | ord-2d6993dc2cee422d87c6adbde503a1a3 |
|---|
| Source note | uspto-grants-2005_08 |
|---|
