Isopropylamine → HCID 22329431, compound

HRID 586424Notes

Reaction equation

HRID 586424 reaction equation
F[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].C(N(CC)CC)C.[CH3:19][CH:20]([NH2:22])[CH3:21]>O1CCCC1>[CH:20]([NH:22][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10])([CH3:21])[CH3:19]

Participants

5

Reactant 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-

Product 1

HCID 22329431HCID 22329431, compoundYield 48.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
25 °C

Procedure

A mixture of 2-fluoro-4-methyl-1-nitrobenzene (250 mg, 1.6 mmol), triethylamine (200 mg, 2.0 mmol), and 2-propanamine (200 mg, 3.4 mmol) in tetrahydrofuran (1 mL) was heated at 25° C. for 5 hours. The crude product was purified by preparative thin-layer chromatography [eluent: hexane/EtOAc (1:2)], giving the desired product (150 mg, 48%).

Workup

  1. customThe crude product was purified by preparative thin-layer chromatography [eluent: hexane/EtOAc (1:2)]

Sources & evidence

ORD record
ord-2d6993dc2cee422d87c6adbde503a1a3
Source dataset
uspto-grants-2005_08
Patent number
US06936607B2

Reaction notes

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