Hydrochloric Acid → HCID 69874127, compound

HRID 586425Notes

Reaction equation

HRID 586425 reaction equation
[CH:1]([NH:4][C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[N+:12]([O-])=O)([CH3:3])[CH3:2].Cl[Sn]Cl.Cl>O>[CH:1]([NH:4][C:5]1[C:6]([NH2:12])=[CH:7][CH:8]=[C:9]([CH3:11])[CH:10]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24479Stannous ChlorideHCID 22329431HCID 22329431, compound

Product 1

HCID 69874127HCID 69874127, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of N-isopropyl-5-methyl-2-nitroaniline (150 mg, 0.77 mmol), SnCl2 (0.5 g, 2.6 mmol), 0.5M HCl (10 mL), and water (20 mL) was stirred at room temperature for 16 hours. The crude product was partitioned in a mixture of aqueous NaHCO3 and CH2Cl2. The organic layer was separated and concentrated to obtain the desired product (120 mg, 95%).

Workup

  1. customThe crude product was partitioned in a mixture of aqueous NaHCO3 and CH2Cl2
  2. customThe organic layer was separated
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-30417b88803a4e83b7bced8917773679
Source dataset
uspto-grants-2005_08
Patent number
US06936607B2

Reaction notes

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