Hydrochloric Acid → HCID 11420633, compound

HRID 586529Notes

Reaction equation

HRID 586529 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[N:16][C:17]([NH:20][C:21]3[N:22]=[CH:23][C:24]4[CH:30]=[C:29]([CH2:31][CH2:32][O:33][CH2:34][CH3:35])[C:28](=[O:36])[N:27]([CH:37]5[CH2:41][CH2:40][CH2:39][CH2:38]5)[C:25]=4[N:26]=3)=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:42]>ClCCl.C(OCC)C>[ClH:42].[CH:37]1([N:27]2[C:25]3[N:26]=[C:21]([NH:20][C:17]4[CH:18]=[CH:19][C:14]([N:11]5[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]5)=[CH:15][N:16]=4)[N:22]=[CH:23][C:24]=3[CH:30]=[C:29]([CH2:31][CH2:32][O:33][CH2:34][CH3:35])[C:28]2=[O:36])[CH2:38][CH2:39][CH2:40][CH2:41]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11342019HCID 11342019, compound

Product 1

HCID 11420633HCID 11420633, compoundYield 97.7%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-{6-[8-Cyclopentyl-6-(2-ethoxy-ethyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-pyridin-3-yl}-piperazine-1-carboxylic acid tert-butyl ester (0.325 g, 0.577 mmol) was dissolved in dichloromethane (4 mL). 2 N HCl in diethyl ether (4 mL) was added and the mixture was stirred at room temperature for 18 hours. The solvent was evaporated to give 8-cyclopentyl-6-(2-ethoxy-ethyl)-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one hydrochloride salt as a yellow solid (0.292 g, 97.7%). MS (APCI) Calc'd for M+H: 449.2. Found: 449.2. Anal. Calc'd for C25H33N7O2 2.6 HCl, 0.35 H2O: C, 52.26; H, 6.56; N, 16.88. Found: C, 52.01; H, 6.96; N, 16.88.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-c13fb302a4844dabb580015982f412e2
Source dataset
uspto-grants-2005_08
Patent number
US06936612B2

Reaction notes

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