HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl 4-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylate → 5-chloro-3-(piperidin-4-yl)-1H-indole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl 4-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylate | HCID 12072033 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-chloro-3-(piperidin-4-yl)-1H-indole hydrochloride | HCID 20345521 | — |
Reaction Steps
tert-butyl 4-(5-chloro-1H-indol-3-yl)piperidine-1-carboxylate (1 g; 2.99 mmol) was dissolved in 7.5 mL of a 4M solution of HCl in dioxane. The mixture was stirred at room temperature for 2 hours and was concentrated under reduced pressure to give quantitatively 5-chloro-3-(piperidin-4-yl)-1H-indole hydrochloride as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434722B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-0fe0be036c7a41ae863ed6512e450b3c |
| Source note | uspto-grants-2016_09 |