反应详情

A solution of 2-bromo-1-(4-methylsulphanylphenyl)-1-ethanone (3.7 g, 15 mmol) in CHCl3 (50 ml) is maintained at a temperature of −5° C. A solution of m-chloroperbenzoic acid (70%, 3.7 g, 15 mmol) in CHCl3 (30 ml) cooled to 0° C. is added dropwise while maintaining an IT of −5° C. to 0° C. After stirring for ½ hour in the cold, the deposited m-chlorobenzoic acid is filtered off. The filtrate is first washed with NaHCO3 solution (8% strength, 50 ml) until acid-free and then rewashed with water (50 ml). The CHCl3 phase dried over Na2SO4 sicc. is concentrated in vacuo. A yellowish residue (1.3 g) results.

1. additionis added dropwise
2. temperaturewhile maintaining an IT of −5° C. to 0° C
3. filtrationis filtered off
4. washThe filtrate is first washed with NaHCO3 solution (8% strength, 50 ml) until acid-free and
5. dry with materialThe CHCl3 phase dried over Na2SO4 sicc
6. concentrationis concentrated in vacuo