HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(Piperidin-4-yl)-1H-indole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(1H-indol-3-yl)piperidine-1-carboxylate | HCID 22405349 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(Piperidin-4-yl)-1H-indole hydrochloride | HCID 22380587 | 97% |
Reaction Steps
tert-butyl 4-(1H-indol-3-yl)piperidine-1-carboxylate (0.6 g; 2.0 mmol) was dissolved in 6 mL of a 4M solution of HCl in dioxane. The mixture was stirred at room temperature for 2 hours and was concentrated under reduced pressure to give 0.46 g (97%) of the desired compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434722B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-1c3b9c79d20b4c61a0fd79232c0ae0ba |
| Source note | uspto-grants-2016_09 |