Hydrochloric Acid → 3-(Piperidin-4-yl)-1H-indole hydrochloride

HRID 58664Notes

Reaction equation

HRID 58664 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[CH:2]1.[ClH:23]>O1CCOCC1>[ClH:23].[NH:13]1[CH2:14][CH2:15][CH:10]([C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22405349tert-Butyl 4-(1H-indol-3-yl)piperidine-1-carboxylate

Product 1

HCID 223805873-(Piperidin-4-yl)-1H-indole hydrochlorideYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-butyl 4-(1H-indol-3-yl)piperidine-1-carboxylate (0.6 g; 2.0 mmol) was dissolved in 6 mL of a 4M solution of HCl in dioxane. The mixture was stirred at room temperature for 2 hours and was concentrated under reduced pressure to give 0.46 g (97%) of the desired compound as a solid.

Workup

  1. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-1c3b9c79d20b4c61a0fd79232c0ae0ba
Source dataset
uspto-grants-2016_09
Patent number
US09434722B2

Reaction notes

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