Iodoethane → HCID 69738490, compound

HRID 586652Notes

Reaction equation

HRID 586652 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[C@H:6]([CH2:7][OH:8])[C:5]1([CH3:23])[C:9]1[CH:18]=[CH:17][C:16]2[C:15]([CH3:20])([CH3:19])[CH2:14][CH2:13][C:12]([CH3:22])([CH3:21])[C:11]=2[CH:10]=1.[Si](OCC1[C@@H](CO)C1(C)C1C=CC2C(C)(C)CCC(C)(C)C=2C=1)(C(C)(C)C)(C)[CH3:25].C(I)C>>[CH2:1]([O:2][CH2:3][CH:4]1[C@@H:6]([CH2:7][OH:8])[C:5]1([CH3:23])[C:9]1[CH:18]=[CH:17][C:16]2[C:15]([CH3:20])([CH3:19])[CH2:14][CH2:13][C:12]([CH3:22])([CH3:21])[C:11]=2[CH:10]=1)[CH3:25]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 69738373HCID 69738373, compoundHCID 131725079HCID 131725079, compound

Product 1

HCID 69738490HCID 69738490, compoundYield 81%

Procedure

Following a procedure similar to that for the preparation of Intermediate 6a using Intermediate 5 as the starting material and ethyl iodide as the alkylating reagent provided the title compound (65 mg, 81% yield) as a colorless oil:

Sources & evidence

ORD record
ord-921ffc8b63714c6680fb4a5eb3712295
Source dataset
uspto-grants-2005_08
Patent number
US06936636B2

Reaction notes

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