1-Benzyl-4-piperidone → 1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydropyridine

Participants

Reaction Steps

Pyrrolidine (31.8 mL, 0.38 mol) was added to a solution of 1-benzyl-4-piperidinone (48.0 g, 0.25 mol) in toluene (180 mL) and the mixture refluxed under Dean-Stark conditions for 4.5 hours. The reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure to give the title compound as an orange oil (61.8 g, 100%).

Provenance & Evidence