反应详情

A mixture of bromobutan-2-one (10 g, 66 mmol), and sodium diformylamide (6.8 g, 72 mmol) in acetonitrile (50 mL) was stirred at room temperature for 3 hours, then warmed to 35° C. for 2 hours. The mixture was stirred for a further 48 hours at room temperature, then filtered, washing through with additional acetonitrile (50 mL). The filtrate was evaporated under reduced pressure to afford the title compound as a clear oil, 9.1 g.

1. temperaturewarmed to 35° C. for 2 hours
2. stirringThe mixture was stirred for a further 48 hours at room temperature
3. filtrationfiltered
4. washwashing through with additional acetonitrile (50 mL)
5. customThe filtrate was evaporated under reduced pressure