1-Benzylpiperazine → HCID 4314202, compound

HRID 586776Notes

Reaction equation

HRID 586776 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[CH2:13]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([N:20]1[CH2:25][CH2:24][N:23]([C:2]2[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=2[C:4]#[N:5])[CH2:22][CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 5194172-Fluoro-5-nitrobenzonitrile

Product 1

HCID 4314202HCID 4314202, compoundYield 89%

Procedure

The experimental protocol used is the same as that described for compound 6.1, 2-fluoro-5-nitrobenzonitrile replacing 2-fluoro-5-nitrotoluene and 1-benzylpiperazine replacing tert-butyl 1-piperazinecarboxylate. A light ochre-coloured solid is obtained (yield 89%). Melting point: 124.0° C.

Workup

  1. customA light ochre-coloured solid is obtained (yield 89%)

Sources & evidence

ORD record
ord-a630b08417e94dee87c927206adfd1ef
Source dataset
uspto-grants-2005_08
Patent number
US06936715B2

Reaction notes

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